Five years ago, "getting Botox" meant one thing. In 2026, there are five FDA-approved botulinum toxin products on the U.S. market.
The Five FDA-Approved Options
Botox (onabotulinumtoxinA)
Botox is the brand name that became the generic term. It has the longest safety record of any cosmetic injectable neurotoxin, with over 20 years of FDA-approved use.
**Onset:** 3–5 days. **Duration:** 3–4 months. **Spread:** Precise control.
Dysport (abobotulinumtoxinA)
Dysport has a slightly different protein structure that causes it to diffuse more broadly from the injection point.
**Onset:** 1–3 days. **Duration:** 3–4 months. **Spread:** Better for large areas like the forehead.
Xeomin (incobotulinumtoxinA)
Xeomin contains only the active botulinum toxin molecule, with no accessory proteins ("Naked Botox").
**Onset:** 3–5 days. **Duration:** 3–4 months. **Spread:** Similar to Botox.
Jeuveau (prabotulinumtoxinA)
#NEWTOX was developed exclusively for aesthetic use.
**Onset:** 2–3 days. **Duration:** 3–4 months. **Spread:** Similar to Botox.
Letybo (letibotulinumtoxinA)
The newest entrant to the U.S. market, though used extensively internationally for years.
**Onset:** 3–5 days. **Duration:** 3–4 months.
Price Comparison
Frequently Asked Questions
Can I switch between Botox and Dysport?
Yes. You can switch between any of these products at any time. There's no medical reason you need to stay with one brand.
Will I need the same number of units regardless of which product I choose?
No. Dysport requires roughly 2.5–3x the units of Botox for equivalent effect. Xeomin, Jeuveau, and Letybo are dosed similarly to Botox.